Here is the full list of all 100 Genome Guardian achievements.
Welcome to Genome Guardian!
Achieve victory in Extract mode at Surface Depth.
Achieve victory in Extract mode at Depth 1.
Achieve victory in Extract mode at Depth 2.
Achieve victory in Extract mode at Depth 3.
Achieve victory in Extract mode at Depth 4.
Achieve victory in Extract mode at Depth 5.
Research for ◇1 after all other research is complete.
Achieve victory in Classic mode at Surface Depth.
Achieve victory in Classic mode at Depth 1.
Achieve victory in Classic mode at Depth 2.
Achieve victory in Classic mode at Depth 3.
Achieve victory in Classic mode at Depth 4.
Achieve victory in Classic mode at Depth 5.
Achieve victory in any mode at Depth 5.
Achieve victory in Brood mode at Surface Depth.
Achieve victory in Brood mode at Depth 1.
Achieve victory in Brood mode at Depth 2.
Achieve victory in Brood mode at Depth 3.
Achieve victory in Brood mode at Depth 4.
Achieve victory in Brood mode at Depth 5.
Defeat The Abyss.
Achieve victory in Abyss mode at Surface Depth.
Achieve victory in Abyss mode at Depth 1.
Achieve victory in Abyss mode at Depth 2.
Achieve victory in Abyss mode at Depth 3.
Achieve victory in Abyss mode at Depth 4.
Achieve victory in Abyss mode at Depth 5.
Research for ◇400.
Achieve victory in any mode 5 times.
Achieve victory in Extract mode.
Eliminate 6666 microbes.
Discover all 69 microbes.
Achieve victory in any mode at Depth 3.
Achieve victory in any mode at Depth 3 (or deeper) with the Reactor perk.
Achieve victory in any mode at Depth 3 (or deeper) with both the Thermometer perk and Extinguisher perk at the same time.
Overheat 100 times.
Achieve victory in any mode with 30 different weapons.
Synthesize all 69 weapons at least once.
Survive wave 50 in any mode at Depth 3 (or deeper).
Extra for ◇8000.
Trigger 100 power-ups.
Achieve victory at Depth 3 (or deeper) with a pinpoint or better than 2° Accuracy weapon.
Achieve victory in any mode at Depth 3 (or deeper) with a weapon that has 360° Accuracy.
Achieve victory in any mode with 20 different perks.
Achieve victory in any mode at Depth 5 with a Burn weapon that didn't originally have Burn.
Have 200 Health (or more) during a run.
Have 300 Health Max (or more) during a run.
Have 30 Shield (or more) during a run.
Have 300 Heat Max (or more) during a run.
Have 500% Critical Damage (or more) during a run.
Have 900% Power-up Chance (or more) during a run.
Have 3000 unspent Biomass (or more) during a run.
Have 10000 unspent Research (or more).
Have a weapon with 1000 DPS (or more) during a run. (honestly this might not trigger on complex weapons with unique functions)
Have a weapon with 1000 Damage (or more) during a run.
Have a weapon with 1000 Knockback (or more) during a run.
Have a weapon with 60/s Firerate during a run.
Have a weapon with 1000 Speed (or more) during a run.
Have 1 of each starter weapon mounted at the same time.
Have 3 of the same tier-4 weapon on a turret with 3 weapon mounts during a run.
Synthesize the same weapon 100 times.
Eliminate 30000 microbes.
Play 100 runs.
Buy 500 items from the shop.
Reroll the shop 300 times.
View the credits via the ? button on the main menu.
Reduce wave time by 15s during a run.
Survive wave 3 before having fired any weapon.
Survive wave 100 in any mode.
Achieve victory in any mode with the Scorch turret and the Funnel perk.
Achieve victory in any mode with the Diesel turret and the Funnel perk.
Achieve victory in any mode with the Buckler turret and the Magnifier, Reactor and Chitin perks.
Achieve victory in any mode with the Surge turret and the Firewall perk.
Achieve victory in any mode with the Colossus turret and the Hourglass perk.
Achieve victory in any mode with the Satellite turret and the Nitro, Mirror and Balloon perks.
Achieve victory in any mode with the Daisy turret and the Prism perk.
Achieve victory in any mode with the Ghost turret and the Microscope and Tire perks.
Achieve(?) defeat in any mode via turret destruction within 4s.
Achieve victory in any mode where only microbes with A DNA aren't extinct.
Achieve victory in any mode where only microbes with C DNA aren't extinct.
Achieve victory in any mode where only microbes with G DNA aren't extinct.
Achieve victory in any mode where only microbes with T DNA aren't extinct.
Achieve victory in any mode without taking a single hit.
Achieve victory in any mode without any perks.
Achieve victory in any mode without any weapon mods.
Achieve victory in any mode without any turret mods.
Achieve victory in any mode 30 times.
Achieve victory in any mode with all currently released turrets.
Achieve victory in any mode at Depth 5 with all currently released turrets.
Achieve victory in any mode with all currently released perks.
Achieve victory in any mode at Depth 5 with all currently released perks.
Achieve victory in any mode with all weapons.