Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
New mode unlocked!
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Alt stage to the basement.
Unlocked a new character.
OMG!
Beat Chest or Dark Room without taking damage.
111% now stop playing!
Built him out of meat cubes.
Unlocked Challenge #11.
Unlocked a new co-player baby.
New boss in the womb!
Isaac now holds the D6!
Unlocked Challenge #19.
Donated 600 pennies to the shop.
Unlocked a new boss!
You are the best!!
They are waiting.
Beat caves without taking damage.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
New boss in the depths!
New boss in the caves!
The game just got harder!
Unlocked Challenge #8.
New boss in the basement!
Donated 200 pennies to the shop.
Donated 100 pennies to the shop.
Beat womb without taking damage.
Unlocked Challenge #6.
Beat depths without taking damage.
Unlocked another miniboss!
Beat basement without taking damage.
Donated 20 pennies to the shop.
You became Lord of the Flies.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked...
Unlocked a new starting item.
Nerd x 1000000
Unlocked a secret.
Greed just got harder!
Unlocked a new item
Unlocked Challenge #24.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Get that song out of her head.
Make a new friend!
Beat the game in Hard mode with Bethany.
Complete the Cathedral with Bethany.
Complete Sheol with Bethany.
Complete the Chest with Bethany.
Complete the Dark Room with Bethany.
Complete Boss Rush with Bethany.
Beat Greed mode with Bethany.
Complete ??? with Bethany.
Beat Greedier mode with Bethany.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Defeat Mega Satan with Bethany.
Beat the game in Hard mode with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the final chapter with Judas.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Kill 10 Battery Bums.
Beat everything in Hard Mode as every character.
Complete the Corpse with Judas.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Complete the final chapter with Magdalene.
Obtain 99 pennies. Then spend every single one of them.
Complete the Corpse with Magdalene.
Spend 40+ pennies in a single shop.
Complete the final chapter with Isaac.
Kids shouldn't believe in fortunes...
The other side is calling...
Defeat Baby Plum 10 times.
Beat Hard mode as Lazarus without losing a life
You are just like your father...
Where could it lead to?
Complete the Corpse with Isaac.
Defeat all bosses in the Mines.
Defeat all bosses in the Mausoleum.
Kill Hornfel before he escapes!
Enter the Corpse...
Defeat all bosses in Downpour.
Complete ??? 3 times.