Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
OMG!
111% now stop playing!
Donated 600 pennies to the shop.
Beat Chest or Dark Room without taking damage.
Unlocked a new co-player baby.
Built him out of meat cubes.
New boss in the womb!
New boss in the caves!
New boss in the basement!
You are the best!!
Donated 200 pennies to the shop.
Beat caves without taking damage.
Beat depths without taking damage.
Unlocked Challenge #11.
Unlocked a new boss!
Unlocked Challenge #19.
You became Lord of the Flies.
Isaac now holds the D6!
New boss in the depths!
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
They are waiting.
Donated 100 pennies to the shop.
Unlocked Challenge #9.
The game just got harder!
Unlocked another miniboss!
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked Challenge #6.
Beat womb without taking damage.
Beat basement without taking damage.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Unlocked Challenge #8.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
They will charge you up... for a small fee.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Lazarus.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Complete the Corpse with Jacob and Esau.
Make a new friend!
Obtain 99 pennies. Then spend every single one of them.
Complete the Corpse with Lilith.
Complete the Corpse with Apollyon.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Complete the Dark Room with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Corpse with ???.
Complete the Corpse with Magdalene.
Kids shouldn't believe in fortunes...
Complete the Corpse with Keeper.
Complete the Corpse with Cain.
Complete the Corpse with the Lost.
Complete the final chapter with Apollyon.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Complete the final chapter with ???.
Complete the final chapter with Cain.
Complete the final chapter with Magdalene.
Complete the final chapter with Samson.
Complete the final chapter with Lazarus.
Complete the final chapter with Eve.
Kill 10 Battery Bums.
Complete the final chapter with Lilith.
Complete the final chapter with Bethany.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with the Forgotten.
Complete the final chapter with the Lost.
Complete the Corpse with Isaac.
Complete the Corpse with Judas.
Complete the final chapter with Isaac.
Defeat Baby Plum 10 times.
Get that song out of her head.
Complete the Corpse with the Forgotten.
Beat Greedier mode with Bethany.
Beat Greed mode with Bethany.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Beat Greedier mode with Jacob and Esau.
Complete the Corpse with Eden.
Spend 40+ pennies in a single shop.
Complete the final chapter with Eden.
Beat Greed mode with Jacob and Esau.
Complete the final chapter with Azazel.
Complete the final chapter with Keeper.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Judas.
The other side is calling...
You are just like your father...
Where could it lead to?
Complete the Corpse with Azazel.
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Enter the Corpse...
Kill Hornfel before he escapes!
Beat Hard mode as Lazarus without losing a life
Defeat all bosses in the Mausoleum.
Complete ??? 3 times.