- Victory!
Finish the game. (Plague Knight)
- Mint Condition
Collect all Cipher Coins. (Plague Knight)
- Maxed Out
Purchase or unlock all relics equipment and upgrades. (Plague Knight)
- Again!
Finish New Game Plus. (Plague Knight)
- Hall Villain
Clear the the Hall of Champions in 3 minutes and 30 seconds or less. (Plague Knight)
- No Damage!
Finish any Stage without taking damage. (Plague Knight)
- Penny Pincher
Finish the game without spending any money... including Cipher Coins! (Plague Knight)
- Naked Plague
Finish the game without collecting any arcana, bomb parts, or armors. (Plague Knight)
- Hurry Up!
Beat the game within 1 hour and 30 minutes. (Plague Knight)
- Checkpointless
Destroy every possible checkpoint in the game. (Plague Knight)
- Untouched
Emerge unscathed from a battle with any Knight of the Order of No Quarter... except for King Knight! (Plague Knight)
- Defend the Lab!
Retake the Explodatorium without breaking any grey blocks during the boss fight. (Plague Knight)
- Trading Up
Trade each of the useless relics to Chester. (Plague Knight)
- Hang Time
Stay in the air for 10 seconds without landing on anything. (Plague Knight)
- Bomb Jump Blitz
Defeat an Order Knight using only bomb jump explosions. (Plague Knight)
- Poor Oolong
Give Oolong a sample of every explosion. (Plague Knight)
- Bomb Economy
Finish any order of no quarter stage using 15 bombs or fewer. (Plague Knight)
- Creep
Watch all of Mona's dance. (Plague Knight)
- Teetotaler
Finish the game without drinking any tonics. (Plague Knight)
- Get Out Of My Room!
Find Plague Knight's secret room. (Plague Knight)