Full list of all 99 The Binding of Isaac achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 52 achievements, and there are 2 DLC packs containing 47 achievements.
Complete the final chapter with Cain
Kill moms heart with Samson
Complete the final chapter with Isaac
Complete the final chapter with Maggy
Complete the final chapter with Judas
Complete the final chapter with Eve
Complete the final chapter with ???
Complete the final chapter with Samson
Kill Satan with Samson
100% the game
Kill mom but pass on 2 treasure room items
Complete Challenge 3
Complete Challenge 1
Complete Challenge 2
Complete Challenge 4
Complete Challenge 6
Complete Challenge 5
Complete Challenge 7
Complete Challenge 8
Complete Challenge 9
???
Beat Mom in Hardmode
Beat Moms Heart in Hardmode
Beat Satan in Hardmode
Beat the boss in the Cathedral in Hardmode
Beat the Game in Hardmode!
Gain 7 Health upgrades from Eternal Hearts
Beat the game as Isaac in Hardmode
Beat the game as Cain in Hardmode
Beat the game as Magdalen in Hardmode
Beat the game as Judas in Hardmode
Beat the game as Samson in Hardmode
Beat the game as Eve in Hardmode
Beat the game as ??? in Hardmode, and good luck!
Beat the game as all characters in Hardmode.
100% the game and hardmode (get all the achievements)