Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
OMG!
111% now stop playing!
Unlocked a new co-player baby.
Unlocked even more bosses!
Unlocked Challenge #11.
Unlocked new bosses!
New boss in the womb!
Alt stage to the womb.
Donated 600 pennies to the shop.
Beat Chest or Dark Room without taking damage.
Beat depths without taking damage.
Unlocked a new character.
New mode unlocked!
Built him out of meat cubes.
Unlocked new enemies!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
You are the best!!
Beat caves without taking damage.
Unlocked Challenge #19.
Unlocked a new boss!
Isaac now holds the D6!
Beat womb without taking damage.
New boss in the caves!
New boss in the depths!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
You became Lord of the Flies.
New boss in the basement!
Donated 200 pennies to the shop.
They are waiting.
The game just got harder!
Donated 100 pennies to the shop.
Unlocked Challenge #6.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked another miniboss!
Donated 20 pennies to the shop.
Beat basement without taking damage.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked Challenge #8.
Destroy 100 rocks.
Nerd x 1000000
Unlocked a new starting item.
Unlocked...
Unlocked a new item
Unlocked Challenge #24.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #27.
Unlocked Challenge #26.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Eve.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard Mode as every character.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Apollyon.
Complete the Corpse with Keeper.
Complete the final chapter with Eve.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the Corpse with Lazarus.
Complete the Corpse with Samson.
Complete the final chapter with Keeper.
Complete the Corpse with Eden.
Complete the final chapter with Magdalene.
Complete the Cathedral with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Corpse with ???.
They will charge you up... for a small fee.
Complete the final chapter with Lazarus.
Complete the Cathedral with Bethany.
Complete Sheol with Bethany.
Complete the Chest with Bethany.
Complete the Dark Room with Bethany.
Complete Boss Rush with Bethany.
Beat Greed mode with Bethany.
Complete ??? with Bethany.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete the Corpse with Isaac.
Complete the Corpse with Cain.
Complete the final chapter with Samson.
Complete the final chapter with Azazel.
Complete the final chapter with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with Jacob and Esau.
Kill 10 Battery Bums.
Complete the Corpse with Judas.
Complete the Corpse with Magdalene.
Complete the final chapter with the Forgotten.
Make a new friend!
Spend 40+ pennies in a single shop.
Complete the Corpse with Azazel.
Complete the final chapter with Lilith.
Defeat Baby Plum 10 times.
Complete the Corpse with Lilith.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the Dark Room with Jacob and Esau.
Kids shouldn't believe in fortunes...
Complete the final chapter with Cain.
Complete the final chapter with Bethany.
Defeat all bosses in the Mausoleum.
Complete Sheol with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Eden.
Complete the final chapter with Isaac.
The other side is calling...
You are just like your father...
Complete the Corpse with Bethany.
Where could it lead to?
Beat the game in Hard mode with Bethany.
Kill Hornfel before he escapes!
Beat Hard mode as Lazarus without losing a life
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Get that song out of her head.
Enter the Corpse...
Obtain 99 pennies. Then spend every single one of them.
Complete ??? 3 times.