Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Alt stage to the womb.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
OMG!
111% now stop playing!
New boss in the womb!
You are the best!!
Unlocked Challenge #11.
Isaac now holds the D6!
Unlocked a new co-player baby.
Unlocked a new boss!
Donated 600 pennies to the shop.
You became Lord of the Flies.
Beat Chest or Dark Room without taking damage.
They are waiting.
New boss in the caves!
Beat womb without taking damage.
Beat depths without taking damage.
Beat caves without taking damage.
Unlocked Challenge #19.
Built him out of meat cubes.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
New boss in the depths!
Unlocked Challenge #9.
New boss in the basement!
Donated 200 pennies to the shop.
Donated 100 pennies to the shop.
The game just got harder!
Unlocked Challenge #6.
Unlocked Challenge #8.
Unlocked another miniboss!
Beat basement without taking damage.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Unlocked Challenge #5.
Unlocked Challenge #10.
Nerd x 1000000
Unlocked a new starting item.
Unlocked Challenge #24.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #27.
Unlocked...
Unlocked Challenge #26.
Unlocked a new item
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
They will charge you up... for a small fee.
Complete the final chapter with the Lost.
Beat everything in Hard Mode as every character.
Complete the Corpse with the Lost.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
Beat everything in Hard mode with Bethany.
Complete the final chapter with the Forgotten.
Complete the final chapter with Apollyon.
Complete the Corpse with Apollyon.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the Corpse with Lazarus.
Complete the Corpse with Judas.
Complete the Corpse with Samson.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Corpse with Bethany.
Complete the Corpse with ???.
Complete the Corpse with the Forgotten.
Complete the final chapter with Lilith.
Kill 10 Battery Bums.
Beat Greed mode with Jacob and Esau.
Complete the final chapter with Lazarus.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Beat Greedier mode with Bethany.
Complete the final chapter with Eve.
Complete the final chapter with Cain.
Complete the Corpse with Eve.
Complete the final chapter with Magdalene.
Complete the Corpse with Lilith.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete the Corpse with Isaac.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Beat the game in Hard mode with Bethany.
Beat Greed mode with Bethany.
Complete the final chapter with ???.
Complete the final chapter with Bethany.
Complete the final chapter with Judas.
Kids shouldn't believe in fortunes...
Complete the final chapter with Samson.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Make a new friend!
Complete the final chapter with Isaac.
Beat Hard mode as Lazarus without losing a life
Complete the final chapter with Azazel.
The other side is calling...
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Obtain 99 pennies. Then spend every single one of them.
Get that song out of her head.
Defeat Baby Plum 10 times.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Spend 40+ pennies in a single shop.
Complete ??? 3 times.