Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
111% now stop playing!
OMG!
Unlocked a new co-player baby.
New boss in the womb!
Beat basement without taking damage.
Donated 600 pennies to the shop.
Donated 200 pennies to the shop.
Built him out of meat cubes.
You are the best!!
Beat Chest or Dark Room without taking damage.
Beat depths without taking damage.
Beat caves without taking damage.
New boss in the caves!
New boss in the basement!
Beat womb without taking damage.
New boss in the depths!
Donated 100 pennies to the shop.
Isaac now holds the D6!
Your future's past waits.
Donated 20 pennies to the shop.
Unlocked a new boss!
The game just got harder!
You became Lord of the Flies.
Unlocked another miniboss!
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #4.
Unlocked Challenge #6.
Unlocked Challenge #7.
Unlocked Challenge #8.
Unlocked Challenge #9.
Unlocked Challenge #11.
Unlocked Challenge #19.
Unlocked Challenge #20.
Destroy 100 rocks.
They are waiting.
Unlocked Challenge #5.
Unlocked Challenge #10.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked Challenge #24.
Unlocked a secret.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #26.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Greed just got harder!
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Complete the final chapter with Judas.
Complete the final chapter with Cain.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with the Lost.
Complete the final chapter with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with the Lost.
They will charge you up... for a small fee.
Complete the Corpse with Bethany.
Complete the final chapter with Apollyon.
Complete the Corpse with the Forgotten.
Beat Greedier mode with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with the Forgotten.
Complete the final chapter with Lilith.
Complete ??? with Bethany.
Make a new friend!
Complete the final chapter with Keeper.
Complete the Corpse with Lilith.
Complete the Corpse with Lazarus.
Complete the final chapter with Eden.
Complete the final chapter with Azazel.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with Lazarus.
Complete the final chapter with Samson.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Cathedral with Bethany.
Complete the Chest with Bethany.
Complete the final chapter with Eve.
Obtain 99 pennies. Then spend every single one of them.
Complete the Corpse with Judas.
Complete the final chapter with Magdalene.
Complete the final chapter with Isaac.
Complete the Corpse with Apollyon.
Complete the final chapter with ???.
Complete the Corpse with Eve.
Complete the Corpse with Keeper.
Kill 10 Battery Bums.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Defeat Baby Plum 10 times.
Complete the Corpse with Azazel.
Complete the Corpse with Samson.
Complete the Corpse with ???.
Complete the Corpse with Isaac.
The other side is calling...
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
You are just like your father...
Where could it lead to?
Complete the Corpse with Eden.
Spend 40+ pennies in a single shop.
Beat the game in Hard mode with Bethany.
Defeat all bosses in the Mausoleum.
Kids shouldn't believe in fortunes...
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Beat Hard mode as Lazarus without losing a life
Enter the Corpse...
Get that song out of her head.
Complete ??? 3 times.