Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
111% now stop playing!
OMG!
Unlocked Challenge #11.
Unlocked a new co-player baby.
Beat depths without taking damage.
Beat Chest or Dark Room without taking damage.
Beat caves without taking damage.
Donated 600 pennies to the shop.
Built him out of meat cubes.
New boss in the womb!
Isaac now holds the D6!
Unlocked Challenge #19.
You became Lord of the Flies.
Unlocked a new boss!
You are the best!!
Unlocked Challenge #8.
They are waiting.
New boss in the caves!
Beat womb without taking damage.
New boss in the basement!
New boss in the depths!
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
Unlocked Challenge #9.
Beat basement without taking damage.
The game just got harder!
Donated 200 pennies to the shop.
Unlocked Challenge #6.
Unlocked another miniboss!
Unlocked Challenge #5.
Unlocked Challenge #10.
Donated 100 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Nerd x 1000000
Unlocked a new starting item.
Unlocked...
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #24.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
They will charge you up... for a small fee.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Corpse with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the Void with Bethany.
Complete ??? with Bethany.
Beat the game in Hard mode with Bethany.
Beat Greedier mode with Bethany.
Beat Greed mode with Bethany.
Complete the Corpse with Eden.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Complete the final chapter with Apollyon.
Complete the Corpse with Apollyon.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the final chapter with Judas.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the final chapter with Lazarus.
Make a new friend!
Complete the Corpse with Lazarus.
Complete the final chapter with Azazel.
Complete the Corpse with Azazel.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Kill 10 Battery Bums.
Complete the final chapter with Eden.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the final chapter with ???.
Complete the Corpse with ???.
Get that song out of her head.
Complete the final chapter with Bethany.
Complete Boss Rush with Bethany.
Complete the Corpse with Cain.
Complete the final chapter with Cain.
Complete the final chapter with Magdalene.
Spend 40+ pennies in a single shop.
Complete the Corpse with Magdalene.
Complete the final chapter with Isaac.
The other side is calling...
Complete the Corpse with Isaac.
Defeat Baby Plum 10 times.
Obtain 99 pennies. Then spend every single one of them.
You are just like your father...
Complete the Corpse with Judas.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Beat Hard mode as Lazarus without losing a life
Kids shouldn't believe in fortunes...
Defeat all bosses in the Mausoleum.
Kill Hornfel before he escapes!
Complete ??? 3 times.