Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Unlocked a new co-player baby.
Beat Chest or Dark Room without taking damage.
Isaac now holds the D6!
New mode unlocked!
Unlocked a new character.
Unlocked even more bosses!
Beat depths without taking damage.
Beat womb without taking damage.
Unlocked new bosses!
New boss in the womb!
Unlocked Challenge #11.
Unlocked Challenge #19.
Built him out of meat cubes.
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new enemies!
Unlocked Challenge #8.
You are the best!!
They are waiting.
You became Lord of the Flies.
Donated 600 pennies to the shop.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
Unlocked a new boss!
The game just got harder!
New boss in the depths!
Unlocked Challenge #6.
Beat caves without taking damage.
New boss in the caves!
Donated 200 pennies to the shop.
New boss in the basement!
Donated 100 pennies to the shop.
Unlocked another miniboss!
Unlocked Challenge #5.
Unlocked Challenge #10.
Beat basement without taking damage.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Nerd x 1000000
Greed just got harder!
Unlocked a secret.
Unlocked Challenge #24.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Kill 10 Battery Bums.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat everything in Hard Mode as every character.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete the final chapter with the Forgotten.
Complete the final chapter with Apollyon.
Complete the final chapter with Keeper.
Complete the final chapter with Lilith.
Complete the final chapter with Eden.
Complete the final chapter with the Lost.
Complete the final chapter with Samson.
Complete the final chapter with Azazel.
Complete the final chapter with Lazarus.
Complete the final chapter with Eve.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the final chapter with Cain.
Complete the final chapter with Magdalene.
Complete the final chapter with Isaac.
The other side is calling...
Complete the Corpse with Jacob and Esau.
Complete the Corpse with the Forgotten.
Complete the Corpse with Apollyon.
Complete the Corpse with Keeper.
Complete the Corpse with Lilith.
Complete the Corpse with the Lost.
Complete the Corpse with Eden.
Complete the Corpse with Lazarus.
Complete the Corpse with Azazel.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Complete the Corpse with ???.
Complete the Corpse with Judas.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Defeat all bosses in the Mausoleum.
Complete the Corpse with Isaac.
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Complete the Void with Jacob and Esau.
Beat the Void with Bethany.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
They will charge you up... for a small fee.
Complete the Dark Room with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete ??? with Bethany.
Complete Sheol with Bethany.
Make a new friend!
Complete Boss Rush with Bethany.
You are just like your father...
Complete the Corpse with Bethany.
Where could it lead to?
Enter the Corpse...
Beat the game in Hard mode with Bethany.
Get that song out of her head.
Kill Hornfel before he escapes!
Beat Greedier mode with Bethany.
Beat Greed mode with Bethany.
Obtain 99 pennies. Then spend every single one of them.
Kids shouldn't believe in fortunes...
Beat Hard mode as Lazarus without losing a life
Defeat Baby Plum 10 times.
Complete ??? 3 times.
Spend 40+ pennies in a single shop.