Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
111% now stop playing!
OMG!
Unlocked a new co-player baby.
Built him out of meat cubes.
Beat Chest or Dark Room without taking damage.
Unlocked Challenge #11.
Beat depths without taking damage.
Donated 600 pennies to the shop.
You became Lord of the Flies.
New boss in the womb!
You are the best!!
Unlocked Challenge #19.
Unlocked a new boss!
They are waiting.
Isaac now holds the D6!
New boss in the basement!
New boss in the caves!
Donated 200 pennies to the shop.
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
New boss in the depths!
Unlocked Challenge #9.
Donated 100 pennies to the shop.
The game just got harder!
Beat caves without taking damage.
Unlocked Challenge #6.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked Challenge #8.
Unlocked another miniboss!
Beat basement without taking damage.
Beat womb without taking damage.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
They will charge you up... for a small fee.
Complete ??? with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the final chapter with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the Corpse with the Forgotten.
Complete the Corpse with Apollyon.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the final chapter with Lilith.
Complete the Corpse with Lilith.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the final chapter with Azazel.
Complete the Corpse with Azazel.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with ???.
Kill 10 Battery Bums.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Beat Greedier mode with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Get that song out of her head.
Complete the Corpse with Cain.
Complete the final chapter with Cain.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete Boss Rush with Bethany.
Make a new friend!
Defeat Baby Plum 10 times.
Complete the final chapter with Bethany.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with the Forgotten.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Obtain 99 pennies. Then spend every single one of them.
Kids shouldn't believe in fortunes...
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the Void with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Corpse with Isaac.
Spend 40+ pennies in a single shop.
Defeat all bosses in the Mines.
Complete the final chapter with Apollyon.
Beat the game in Hard mode with Jacob and Esau.
Defeat all bosses in the Mausoleum.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete ??? with Bethany.
Complete the final chapter with Isaac.
The other side is calling...
You are just like your father...
Complete the Corpse with Bethany.
Where could it lead to?
Enter the Corpse...
Beat the game in Hard mode with Bethany.
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.