Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Unlocked a new co-player baby.
Donated 600 pennies to the shop.
Unlocked a new character.
New mode unlocked!
Beat depths without taking damage.
Donated 200 pennies to the shop.
Built him out of meat cubes.
Beat Chest or Dark Room without taking damage.
Unlocked even more bosses!
New boss in the womb!
Alt stage to the womb.
Unlocked new bosses!
Unlocked Challenge #11.
You are the best!!
They are waiting.
Unlocked new enemies!
Alt stage to the depths.
Isaac now holds the D6!
Donated 100 pennies to the shop.
Alt stage to the caves.
New boss in the caves!
Beat womb without taking damage.
New boss in the basement!
You became Lord of the Flies.
Beat caves without taking damage.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #19.
Alt stage to the basement.
Your future's past waits.
New boss in the depths!
Unlocked Challenge #9.
The game just got harder!
Unlocked Challenge #6.
Unlocked a new boss!
Beat basement without taking damage.
Donated 20 pennies to the shop.
Unlocked another miniboss!
Unlocked Challenge #8.
Destroy 100 rocks.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked Challenge #5.
Unlocked Challenge #10.
Nerd x 1000000
Unlocked a new starting item.
Unlocked...
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #24.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
They will charge you up... for a small fee.
Kill 10 Battery Bums.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Complete ??? with Bethany.
Complete the final chapter with Apollyon.
Complete the final chapter with Bethany.
Complete the Corpse with Apollyon.
Complete the Corpse with Bethany.
Beat Greedier mode with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete the final chapter with Lazarus.
Complete the final chapter with the Forgotten.
Kids shouldn't believe in fortunes...
Complete the Corpse with Jacob and Esau.
Complete the Corpse with the Forgotten.
Complete the Corpse with ???.
Complete the Corpse with Lazarus.
Complete the final chapter with ???.
Complete the final chapter with Azazel.
Complete the Corpse with Keeper.
Complete the Corpse with Azazel.
Complete the final chapter with Keeper.
Complete the final chapter with Magdalene.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with Cain.
Complete the Cathedral with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Defeat Baby Plum 10 times.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Eden.
Complete the final chapter with Lilith.
Complete the final chapter with the Lost.
Complete the final chapter with Samson.
Make a new friend!
Complete the Corpse with Samson.
Complete the Corpse with the Lost.
Complete the Corpse with Eden.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Defeat all bosses in the Mausoleum.
Complete the Corpse with Lilith.
Obtain 99 pennies. Then spend every single one of them.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with Isaac.
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
The other side is calling...
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Spend 40+ pennies in a single shop.
You are just like your father...
Where could it lead to?
Complete the Corpse with Isaac.
Enter the Corpse...
Kill Hornfel before he escapes!
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Beat the game in Hard mode with Bethany.
Complete the Cathedral with Bethany.
Beat Hard mode as Lazarus without losing a life
Get that song out of her head.
Complete ??? 3 times.