Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Unlocked a new co-player baby.
Unlocked even more bosses!
New boss in the womb!
Unlocked Challenge #11.
Unlocked new bosses!
Unlocked a new character.
Alt stage to the womb.
New mode unlocked!
You are the best!!
Beat Chest or Dark Room without taking damage.
Isaac now holds the D6!
Unlocked Challenge #19.
They are waiting.
Unlocked new enemies!
Alt stage to the depths.
Donated 600 pennies to the shop.
Alt stage to the caves.
You became Lord of the Flies.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Alt stage to the basement.
Unlocked a new boss!
Unlocked Challenge #9.
Beat womb without taking damage.
The game just got harder!
Beat depths without taking damage.
Unlocked Challenge #8.
Beat caves without taking damage.
Donated 200 pennies to the shop.
New boss in the depths!
Unlocked Challenge #6.
New boss in the caves!
Built him out of meat cubes.
Donated 100 pennies to the shop.
Unlocked another miniboss!
New boss in the basement!
Unlocked Challenge #5.
Unlocked Challenge #10.
Donated 20 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Beat basement without taking damage.
Destroy 100 rocks.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked Challenge #24.
Unlocked a secret.
Unlocked Challenge #27.
Greed just got harder!
Unlocked Challenge #26.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Complete the final chapter with Samson.
Beat everything in Hard Mode as every character.
Complete the Corpse with Samson.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the final chapter with Apollyon.
Complete the Corpse with Apollyon.
Complete the final chapter with Lilith.
Complete the Corpse with Lilith.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Complete the Corpse with Eden.
Complete the Corpse with Cain.
Complete the final chapter with Isaac.
Complete the final chapter with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Complete the final chapter with Bethany.
Defeat Mega Satan with Bethany.
Complete the final chapter with Eden.
Complete the final chapter with Cain.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete the final chapter with the Forgotten.
Kill 10 Battery Bums.
They will charge you up... for a small fee.
Beat Greedier mode with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete the Corpse with Isaac.
Kids shouldn't believe in fortunes...
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete the Corpse with the Forgotten.
Complete the final chapter with Azazel.
The other side is calling...
Obtain 99 pennies. Then spend every single one of them.
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Make a new friend!
Defeat Baby Plum 10 times.
Spend 40+ pennies in a single shop.
Defeat all bosses in the Mausoleum.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Enter the Corpse...
Get that song out of her head.
Defeat all bosses in Downpour.
Complete Boss Rush with Bethany.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.