Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
111% now stop playing!
OMG!
Unlocked Challenge #11.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Isaac now holds the D6!
Donated 600 pennies to the shop.
Built him out of meat cubes.
Beat Chest or Dark Room without taking damage.
Beat caves without taking damage.
Unlocked a new co-player baby.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
New boss in the basement!
New boss in the caves!
New boss in the depths!
The game just got harder!
Your future's past waits.
Beat basement without taking damage.
Beat depths without taking damage.
Beat womb without taking damage.
You are the best!!
Unlocked a new boss!
New boss in the womb!
Unlocked another miniboss!
Donated 20 pennies to the shop.
Donated 100 pennies to the shop.
Donated 200 pennies to the shop.
They are waiting.
Unlocked Challenge #4.
Unlocked Challenge #6.
Unlocked Challenge #7.
Unlocked Challenge #8.
Unlocked Challenge #9.
Unlocked Challenge #19.
Unlocked Challenge #20.
You became Lord of the Flies.
Destroy 100 rocks.
Unlocked Challenge #5.
Unlocked Challenge #10.
Nerd x 1000000
Unlocked...
Unlocked a new item
Unlocked a new starting item.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #24.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked a hidden chapter.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.
Complete the final chapter with the Lost.
Complete the final chapter with Lilith.
Complete the final chapter with Keeper.
Complete the final chapter with the Forgotten.
Complete the final chapter with Apollyon.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with Eden.
Complete the final chapter with Lazarus.
Complete the final chapter with Samson.
Complete the final chapter with Eve.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the final chapter with Cain.
Complete the final chapter with Magdalene.
Complete the final chapter with Isaac.
Complete the Corpse with the Lost.
Complete the Corpse with the Forgotten.
Kids shouldn't believe in fortunes...
Complete the Corpse with Lilith.
Complete the Corpse with Keeper.
Complete the Corpse with Apollyon.
Complete the Corpse with Bethany.
Complete the Corpse with Lazarus.
Complete the Corpse with Eden.
Complete the Corpse with ???.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Kill 10 Battery Bums.
Complete the Corpse with Judas.
Complete the Corpse with Cain.
Beat Greedier mode with Jacob and Esau.
Obtain 99 pennies. Then spend every single one of them.
Beat Greed mode with Jacob and Esau.
Complete the Corpse with Magdalene.
Complete the Corpse with Isaac.
Beat the Void with Bethany.
Make a new friend!
Complete the final chapter with Azazel.
The other side is calling...
Complete the Dark Room with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete Boss Rush with Bethany.
Complete Sheol with Bethany.
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Defeat all bosses in the Mines.
Beat Greedier mode with Bethany.
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Complete ??? with Bethany.
Beat the game in Hard mode with Bethany.
Get that song out of her head.
Defeat all bosses in Downpour.
Kill Hornfel before he escapes!
Defeat Baby Plum 10 times.
Beat Greed mode with Bethany.
Spend 40+ pennies in a single shop.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.