Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
OMG!
111% now stop playing!
Unlocked a new co-player baby.
Built him out of meat cubes.
Beat Chest or Dark Room without taking damage.
You became Lord of the Flies.
Unlocked Challenge #11.
You are the best!!
Unlocked Challenge #19.
New boss in the womb!
Donated 600 pennies to the shop.
Isaac now holds the D6!
Unlocked a new boss!
New boss in the caves!
New boss in the basement!
They are waiting.
New boss in the depths!
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
Beat womb without taking damage.
Unlocked Challenge #9.
Unlocked Challenge #8.
Donated 200 pennies to the shop.
The game just got harder!
Beat caves without taking damage.
Donated 100 pennies to the shop.
Unlocked another miniboss!
Unlocked Challenge #6.
Beat depths without taking damage.
Donated 20 pennies to the shop.
Beat basement without taking damage.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Unlocked Challenge #5.
Unlocked Challenge #10.
Nerd x 1000000
Unlocked a new starting item.
Unlocked...
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Beat everything in Hard mode with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the final chapter with the Lost.
Complete Sheol with Jacob and Esau.
Complete the Corpse with Lilith.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with Lilith.
Complete the Corpse with Keeper.
Complete the Corpse with Apollyon.
Complete ??? with Bethany.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Lazarus.
Get that song out of her head.
Complete the final chapter with Lazarus.
Complete the final chapter with Samson.
Complete the final chapter with Eden.
Complete the final chapter with Bethany.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Corpse with Azazel.
Complete the Corpse with Eve.
Complete the Corpse with Samson.
Complete the final chapter with ???.
Make a new friend!
Complete the Corpse with Eden.
Complete the final chapter with Eve.
Kill 10 Battery Bums.
Complete the Corpse with ???.
Complete the final chapter with Keeper.
Defeat Mega Satan with Bethany.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Azazel.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Complete the final chapter with Apollyon.
Complete the Corpse with the Forgotten.
Complete the Corpse with Bethany.
Complete the final chapter with Cain.
Complete the final chapter with Magdalene.
Complete the final chapter with the Forgotten.
They will charge you up... for a small fee.
Defeat Baby Plum 10 times.
Complete the final chapter with Isaac.
Complete the Corpse with Magdalene.
Complete the Corpse with Cain.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete the Corpse with the Lost.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Beat the game in Hard mode with Bethany.
The other side is calling...
Complete Boss Rush with Bethany.
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Obtain 99 pennies. Then spend every single one of them.
Spend 40+ pennies in a single shop.
Kids shouldn't believe in fortunes...
Defeat all bosses in the Mines.
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Beat Hard mode as Lazarus without losing a life
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Complete ??? 3 times.