Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
OMG!
111% now stop playing!
Unlocked a new co-player baby.
Unlocked even more bosses!
Alt stage to the womb.
New boss in the womb!
Donated 600 pennies to the shop.
Unlocked a new character.
Unlocked new bosses!
Unlocked Challenge #11.
New mode unlocked!
You are the best!!
Unlocked new enemies!
Unlocked Challenge #19.
Beat Chest or Dark Room without taking damage.
They are waiting.
Alt stage to the depths.
Beat depths without taking damage.
Beat caves without taking damage.
New boss in the caves!
Alt stage to the caves.
New boss in the depths!
New boss in the basement!
Isaac now holds the D6!
Unlocked a new boss!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Alt stage to the basement.
Unlocked Challenge #9.
Beat basement without taking damage.
Donated 200 pennies to the shop.
Beat womb without taking damage.
You became Lord of the Flies.
Unlocked Challenge #5.
Unlocked Challenge #10.
The game just got harder!
Unlocked Challenge #6.
Unlocked Challenge #8.
Unlocked another miniboss!
Donated 100 pennies to the shop.
Built him out of meat cubes.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Unlocked a new starting item.
Unlocked...
Unlocked a new item
Nerd x 1000000
Unlocked Challenge #24.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new challenge.
Unlocked a new area.
Beat everything in Hard Mode as every character.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the final chapter with Samson.
Complete the final chapter with Cain.
Complete the final chapter with Lilith.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Apollyon.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Complete the Corpse with Cain.
Complete the Corpse with ???.
Complete the Corpse with Eve.
Complete the Corpse with Samson.
Complete the Corpse with Azazel.
Complete the Corpse with Lilith.
Complete the Corpse with Apollyon.
Complete the Corpse with the Forgotten.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Complete the Corpse with Jacob and Esau.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete the Corpse with Lazarus.
They will charge you up... for a small fee.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with Eve.
Complete the final chapter with the Forgotten.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with Eden.
Kill 10 Battery Bums.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Obtain 99 pennies. Then spend every single one of them.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with ???.
Complete the final chapter with Lazarus.
Complete the Corpse with the Lost.
Kids shouldn't believe in fortunes...
Complete the final chapter with the Lost.
Complete the Corpse with Isaac.
Complete the final chapter with Bethany.
Beat Hard mode as Lazarus without losing a life
Make a new friend!
Defeat Baby Plum 10 times.
Complete the final chapter with Azazel.
Spend 40+ pennies in a single shop.
Kill Hornfel before he escapes!
Complete the final chapter with Isaac.
The other side is calling...
You are just like your father...
Complete the Corpse with Eden.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in Downpour.
Get that song out of her head.
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Complete ??? 3 times.