Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
OMG!
111% now stop playing!
Donated 600 pennies to the shop.
Built him out of meat cubes.
Unlocked a new co-player baby.
New boss in the womb!
You are the best!!
Unlocked Challenge #11.
Unlocked Challenge #19.
Isaac now holds the D6!
Beat Chest or Dark Room without taking damage.
Donated 200 pennies to the shop.
They are waiting.
Unlocked a new boss!
New boss in the caves!
New boss in the basement!
New boss in the depths!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
You became Lord of the Flies.
Unlocked Challenge #9.
Donated 100 pennies to the shop.
Beat caves without taking damage.
Beat basement without taking damage.
Unlocked Challenge #8.
Unlocked another miniboss!
Beat depths without taking damage.
The game just got harder!
Beat womb without taking damage.
Unlocked Challenge #6.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked Challenge #24.
Unlocked Challenge #27.
Unlocked a secret.
Unlocked Challenge #26.
Greed just got harder!
Unlocked a new item
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Make a new friend!
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Chest with Jacob and Esau.
Complete the Chest with Bethany.
Beat everything in Hard mode with Bethany.
Complete the Cathedral with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Corpse with Bethany.
Complete the Corpse with the Forgotten.
Complete the Corpse with Apollyon.
Complete the Corpse with Keeper.
Complete the Corpse with Lilith.
Complete the Corpse with the Lost.
Complete the Corpse with Eden.
Complete the Corpse with Lazarus.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Complete the Corpse with ???.
Defeat all bosses in the Mines.
Complete the Corpse with Judas.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Complete the Corpse with Isaac.
Get that song out of her head.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat Greedier mode with Bethany.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with Bethany.
Complete the final chapter with the Forgotten.
Complete the final chapter with Apollyon.
Complete the final chapter with Keeper.
Complete the final chapter with Lilith.
Complete the final chapter with Eden.
Defeat all bosses in the Mausoleum.
Complete the final chapter with Lazarus.
Complete the final chapter with Samson.
Complete the final chapter with the Lost.
Complete the final chapter with Eve.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the final chapter with Cain.
Complete the final chapter with Magdalene.
Complete the final chapter with Isaac.
Complete the final chapter with Azazel.
The other side is calling...
Complete ??? with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Enter the Corpse...
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Beat Greed mode with Bethany.
Obtain 99 pennies. Then spend every single one of them.
They will charge you up... for a small fee.
Beat the Void with Bethany.
Complete ??? with Bethany.
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Kill 10 Battery Bums.
Kids shouldn't believe in fortunes...
Spend 40+ pennies in a single shop.
Defeat Baby Plum 10 times.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.