Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
111% now stop playing!
OMG!
Unlocked a new co-player baby.
Built him out of meat cubes.
Unlocked Challenge #11.
Donated 600 pennies to the shop.
New boss in the womb!
Beat caves without taking damage.
You are the best!!
Isaac now holds the D6!
Unlocked a new boss!
Unlocked Challenge #19.
New boss in the caves!
Donated 200 pennies to the shop.
New boss in the basement!
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
New boss in the depths!
Beat Chest or Dark Room without taking damage.
They are waiting.
Beat womb without taking damage.
Unlocked Challenge #9.
The game just got harder!
You became Lord of the Flies.
Beat depths without taking damage.
Unlocked Challenge #6.
Donated 100 pennies to the shop.
Unlocked another miniboss!
Unlocked Challenge #5.
Unlocked Challenge #10.
Beat basement without taking damage.
Unlocked Challenge #8.
Destroy 100 rocks.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Donated 20 pennies to the shop.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Kids shouldn't believe in fortunes...
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Corpse with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the Corpse with the Lost.
Complete the final chapter with Lazarus.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Complete the final chapter with ???.
Complete the Corpse with ???.
They will charge you up... for a small fee.
Complete the Corpse with Cain.
Complete the final chapter with Cain.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Complete the final chapter with the Forgotten.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Make a new friend!
Kill 10 Battery Bums.
Complete the Corpse with Magdalene.
Defeat Baby Plum 10 times.
Complete the final chapter with the Lost.
Complete the final chapter with Magdalene.
Complete the final chapter with Isaac.
Complete the final chapter with Azazel.
Complete the Corpse with Isaac.
Obtain 99 pennies. Then spend every single one of them.
Beat the Void with Bethany.
Complete the Corpse with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the Chest with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete the Cathedral with Bethany.
The other side is calling...
Complete the Corpse with the Forgotten.
Complete Sheol with Bethany.
Beat the game in Hard mode with Bethany.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete the Corpse with Azazel.
You are just like your father...
Complete the Corpse with Lazarus.
Where could it lead to?
Enter the Corpse...
Beat Hard mode as Lazarus without losing a life
Defeat all bosses in the Mausoleum.
Defeat all bosses in Downpour.
Spend 40+ pennies in a single shop.
Defeat all bosses in the Mines.
Get that song out of her head.
Kill Hornfel before he escapes!
Complete ??? 3 times.